Through the USAID Office of HIV/AIDS, GHSC-PSM received funds to explore the use of drones for HIV/AIDS commodity deliveries to isolated and difficult-to-reach communities and to better understand the potential to improve health outcomes in low resource settings. The resulting activity was designed to focus on rural settings which experience limitations in the existing distribution system and lab sample network. These limitations, coupled with geographic and infrastructure challenges, leave gaps in service provided to patients. The activity included research into existing drone delivery activities, current drone technology, government regulations, feasibility assessments of numerous countries and scoping visits, public procurement for drone services, and collaborative activity design sessions in the selected country. The activity report highlights key lessons learned and recommendations for future drone delivery implementation.