This document was developed by UNICEF with contributions from members of the Interagency Supply Chain Group (ISG). Its development was motivated during the Health Systems Strengthening Workshop hosted by UNICEF in 2018 when national government representatives collectively and unanimously expressed concerns about increasing demands for engagement in assessments of national supply chains for medicines and health products. They expressed a critical need for guidance on selecting the most appropriate tools in order to improve the focus and usefulness of the resulting information.